There is a higher rate of transient atrial fibrillation post PFO closure device placement, the long-term effects of which have yet to be studied.Ītrial fibrillation Atrial septal aneurysm Cryptogenic stroke Patent foramen ovale Transcatheter closure Transient ischemic attack.Ĭopyright © 2018 Elsevier Inc. However, PFO closure in these patients has not been shown to reduce the risk of recurrent TIA or all-cause mortality.
COMPREHENSIVE META ANALYSIS 3 PLUS
The results of this meta-analysis suggest that transcatheter closure of PFO plus medical therapy is superior to medical therapy alone for the prevention of recurrent cryptogenic stroke.
Patients undergoing PFO closure were more likely to develop transient atrial fibrillation than medical therapy alone (OR: 5.85 CI: 3.06-11.18, p ≤0.0001) whereas the risk of bleeding was similar between the groups (OR: 0.93 CI: 0.55-1.57, p = 0.78). There was no difference in all-cause mortality between two groups (OR 0.73, CI 0.33-1.58, p = 0.42). Risk of recurrent stroke was significantly lower in the PFO closure plus medical therapy group compared to medical therapy alone.
The odds ratios (OR) with 95% confidence interval (CI) were computed and p < 0.05 was considered as a level of significance.Ī total of 1889 patients were assigned to PFO closure plus medical therapy and 1861 patients were assigned to medical therapy only. End points were recurrent stroke, TIA and all-cause mortality. Six RCTs (n = 3750) comparing PFO closure with medical therapy were included in the analysis. PubMed and the Cochrane Center Register of Controlled Trials were searched for studies published through June 2018, comparing PFO closure plus medical therapy versus medical therapy alone. This meta-analysis aims to compare rates of recurrent stroke, transient ischemic attack (TIA) and all-cause mortality with PFO closure and medical therapy vs. Previous randomized controlled trials (RCTs) comparing transcatheter PFO closure with medical therapy in patients with cryptogenic stroke to prevent recurrent ischemic stroke showed mixed results. However, given the fact that the frequency of occurrence of HPV in lung tumor tissue varies greatly, a question may arise about the real role of HPV in LC carcinogenesis, which makes further research relevant and promising.Ĭase–control study HPV Human papillomavirus Lung cancer Meta-analysis Overview.The ideal treatment strategy for patients with cryptogenic stroke and patent foramen ovale (PFO) is not yet clear. Program, which included 26 studies, the results of which revealed: the prevalence of HPV infection in tumor lung tissue was compared with normal lung tissue OR (95% CI) = 5.38 (3.21-9.00) p < 0.0001, significance was also found for Chinese studies OR = 6.3, 95% CI 3.42-11.53, p < 0.0001, I2 = 71.8% and for nine studies in Europe OR = 6.3, 95% CI 1.8-22.18, p = 0.004, I2 = 51.0%. A meta-analysis of the prevalence of HPV was conducted using Comprehensive Meta-Analysis 3.0. Low-oncogenic types (6 and 11) are also predominantly observed in Asia (39.9%), while in Europe and North America 30% and 12.8%, respectively. Interestingly, the highest occurrence of high oncogenic types (16 and 18) is observed in Asia (40.3%), then in Latin America (33.6%), Europe (25.6%) and North America (15.4%). But the highest percentage of HPV occurrence by region is observed in Latin America (33.5%), followed by the Asian countries (31%), in European countries the frequency is 18%. The highest average percent of occurrence of this virus is shown for such countries as: Brazil, Korea, Greece and Taiwan (more than 40%). The absence of a virus among lung cancer patients has been established for Canada, the Netherlands and Singapore. It has been widely used in medicine, psychology, pedagogy, management, economics, and other disciplines ( Rosenthal and DiMatteo, 2001 ). Meta-analysis is a statistical method for comprehensively and systematically analyzing many research results ( Hedges, 1985 ).
Of all the analyzed studies (9195 patients), 12 works showed a complete absence of HPV in the biological material in patients with LC. This study used Comprehensive Meta-Analysis 3.0 software.
HPV is recognized as the etiological factor of cervical cancer, however, there is widespread evidence that this virus is detected not only in gynecological carcinomas, but also in tumors of other organs, in particular the upper respiratory tract and digestive tract.Ī search was conducted to a depth of 29 years in the PubMed, Web of Science, Scopus, databases. This review is devoted to assessing the prevalence of human papillomavirus (HPV) in lung cancer (LC) in the world.
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